Inigo.Mind

Neuro-Motor-Engine

Rewiring motor control through play

We build games that reward children for controlling their own movement. Each session turns the brain's ability to rewire itself into a skill a child can practice, measured in real time and guided by clinicians.

Our first product, XTICS, helps children with tic disorders. It was tested in a published, controlled trial at Tel Aviv Sourasky Medical Center (Ichilov), where it is now used with patients.

Partner with us See the evidence
Published in Movement Disorders & European Journal of Neurology (2024) Registered trial NCT06348511 Built with Tel Aviv Sourasky Medical Center

The problem

Medication no one wants.
Therapy no one can reach.

Tics are sudden, repetitive movements or sounds. For many children they bring bullying, isolation and real psychological harm. The first-line treatment works, but almost no one can get it.

~1.4M

US children live with a persistent (chronic) tic disorder.

~429

certified CBIT therapists serve the entire US. Families wait 9–12 months for a first session.

50%

of children drop out of in-clinic behavioral therapy before finishing. Practice between sessions goes unmeasured.

Behavioral therapy (CBIT)

  • Eight one-hour sessions with a rare specialist
  • $1,200–3,500 per course, with patchy US coverage
  • Harder to deliver to the 63% of children who also have ADHD

Medication

  • Only repurposed drugs are approved for tics
  • Antipsychotics work but bring weight gain, stiffness and Parkinson-like side effects
  • Alpha-2 agonists are gentler and less effective

Prevalence: US CDC, Tourette Syndrome Data & Statistics. Therapist and access figures: Inigo.Mind market research.

The engine

A reward loop that trains the brain

The game watches for the movement a child is learning to control and rewards them the moment they succeed. Repeated across short, fun sessions, that loop builds new motor-control habits.

Trigger Action Reward XTICS one session Clinical capture Neuromodulation

  1. Detect

    Computer vision through a standard camera spots and counts each child's individual tic patterns, so no one has to code them by hand.

  2. Personalize

    Rewards and difficulty adapt to the child's tic profile, progress, age and engagement, which keeps them challenged and coming back.

  3. Measure & learn

    Clinicians and parents see tics, progress and adherence session by session. Every session makes the next one smarter.

The goal: neuroplasticity

The brain's physical ability to rewire itself by forming new connections.

The tool: neuromodulation

Shaping nerve activity through immediate, contingent reward to drive that rewiring.

The evidence

Published, controlled, already treating patients

XTICS was tested in a randomized crossover trial of 35 children aged 7–15 at Tel Aviv Sourasky Medical Center, with tic severity scored by blinded clinicians.

100%

adherence. Every child completed every session.

25.7%

reduction on the clinical YGTSS scale after just six sessions.

42%

reduction in tic severity reported by parents (PTQ) after three months.

~1500%

increase in the time between tics within 11 game sessions.

The reward is the mechanism. When the game stopped rewarding suppression, the effect was significantly smaller. That points to the engine itself, not to the children simply getting used to the setting.

Movement Disorders · 2024 Gamified closed-loop intervention enhances tic suppression in children Rotstein M, … Raz G. European Journal of Neurology · 2024 Impact of movie and video game elements on tic manifestation in children Raz G, et al. ClinicalTrials.gov · NCT06348511 XTics: a gamified enhancer of non-pharmacological interventions in tic disorders Trial registration

First product

XTICS turns tic suppression into a game kids want to win

An adventure world children play on a tablet or computer, in the clinic or at home. Behind the cards and castles, every move forward is earned by practicing tic control.

  • Ages 5–12, short sessions, no adult needed during play
  • Camera-based tic recognition, no extra hardware at home
  • Progress dashboard for clinicians and parents
The XTICS site for families →
The XTICS adventure map: a path winding through cliffs, bridges and castles, with character cards
The adventure map. Each step along the path is earned in practice.
XTICS gameplay screens shown alongside brain imaging renders
Gameplay moments are timed to the reward loop.
It's been almost a month with no tics at all! This comes after 6 years of tics without a break.
Parent of an 8-year-old boy
She learned how to cope and redirect them so that externally they are not visible at all. Mentally, she practices every day.
Parent of an 11-year-old girl
There has been significant improvement. He is applying the methods he learned. He has learned to control his tics.
Parent of a 9-year-old boy

Comments from parents of children in the XTICS clinical study. Names are withheld for privacy. Individual results vary.

For clinics & hospitals

Treat the patients you refer away today

Hundreds of US pediatric neurology and movement-disorder clinics diagnose tics, then send families away because there is no CBIT therapist on staff. XTICS lets them start treatment in-house.

In clinic and at home

Sessions run in the clinic, and a home companion app lets children practice between visits, with every session measured.

Fits the referral workflow

Assessment, treatment, monitoring and outcomes in one place, so clinicians see progress without coding tics by hand.

Simple to start

Start per completed patient course, then move to a site license as volume grows. One platform, with new indications added to the same clinic.

1.4Mchildren with chronic tics
700Kdiagnosed
600Kmild to moderate
100–300Kvisit a clinic each year

Pipeline

One engine, many indications

The clinics that treat tics also treat cerebral palsy and brain injury, often with the same therapists. Each new indication is a new product for a clinic we already serve.

Treating patients

Tics

First indication. In use at Tel Aviv Sourasky after the clinical trial.

Multi-center clinical trials

Cerebral palsy

Second indication. Same clinics, same engine.

Research

Stroke & TBI

Extending the platform to pediatric rehabilitation.

Done

  • Two generations of the game completed
  • Clinical trial at Ichilov; results published in two journals (2024)
  • Treating patients at Ichilov
  • Engine patents

In flight

  • Computer vision that automates tic coding
  • MOU with Ichilov
  • Patent filings for CP and TBI
  • Cerebral palsy clinical trial

Next

  • Commercial-ready platform: clinician dashboard + patient app
  • FDA 510(k) submission
  • 10–20 contracted US clinical sites

Team

Neuroscience, movement disorders, gaming and technology

Founders

Medical advisory board

CEO

Nitzan Rozenberg

Enterprise B2B sales and delivery of complex interactive systems.

Juno · Tel Aviv University
CBO

Muli Bh. Shahar

Neuroscience business and commercial strategy.

NeuroDerm · Mitsubishi Tanabe Pharma · Onerji
CPO

Rotem Levim

Game design and user engagement.

Juno · Tel Aviv University
Media neuroscience

Dr. Gal Raz

Media neuroscience and behavior research. Lead researcher on the XTICS studies.

Sagol School of Neuroscience, Tel Aviv University · Tel Aviv Sourasky Medical Center
Neuro-rehabilitation

Dr. Alexis Mitelpunkt

Neuro-rehabilitation and clinical data.

Tel Aviv University · Tel Aviv Sourasky Medical Center

Work with us

Building with investors and US pediatric clinics

We're partnering with investors and clinical sites to bring the engine to US clinics. If that's you, let's talk.

Start a conversation

Contact

Let's talk

Investors, clinicians, researchers and partners: send us a note and the right person will reply.

Based in
Tel Aviv, Israel

Families looking for XTICS: please visit the XTICS site.

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